Iraqi Pharmaceutical Formula for Griseofulvin Oral Suspension 125 mg /5 ml w/v is a Fungistatic Antibiotic, with it is Stability Study. 12- تركيبة صيدلانية عراقية لمستحضر معلق فموي كريسيوفولفين 125ملغم /5 مل وزن/ حجم كمضاد حيوي ضد الفطريات مع دراسة ثباتيتها

Abstract

Abstract This work has been carried out to develop national drug product contains )125mg / 5ml( griseofulvin as oral suspension is used to treat fungal infections of the skin, hair, and nails that do not respond to creams or lotions.Several formulations were prepared using different suspensions bases, preservatives and suspending agent. Selection of best formula relied solely on physic-chemical testing of sample exposed to thermal stresses.Stability study was conducted on the product for (6) months at different temperatures to determine the expiration date and the best storage conditions . From the study we obtained fungistatic antibiotic suspension of good homogeneity. The expiry date calculated to be not less than (2) years.