Formulation and Evaluation of Calcium Gluconate 2.5 % (w/w) Topical Gel.

Abstract

Abstract This work has been carried out to formulation and evaluation pharmaceutical product containing calcium gluconate (2.5 % w/w) as topical gel, which is indicated in burns of hydrofluoric acid exposure to the body. Different formulations were prepared using variable gel bases، preservatives and humectants . Selection of best formula relied solely on physic-chemical testing of sample exposed to thermal stresses. The stability study was conducted on the product for (6) months at different temperatures (40، 50 and 60) ◦C to determine the expiration date and the best storage conditions. The study revealed gel of good homogeneity, softness and adhesivity . Expiry date with an not less than (2) years.