Formulation of Acyclovir 3% (w / w) As An Eye Ointment

Abstract

This work has been carried out to formulate drug product contains (3 %w/w) acyclovir as an eye ointment, it is used to treat an eye infection mainly herpes simplex keratitis. Several formulations were prepared using different eye ointment bases . Selection of best formula relied solely on physicochemical testing of sample exposed to different thermal stresses . The stability study was conducted on the product for (6) months at different temperatures (30 ، 40 ، 50) °C to determine the expiration date and the best storage conditions . From the study we obtained an antiviral eye ointment of good homogeneity ، softness and adhesivity . The expiry date calculated to be not less than (3) years