Iraqi Pharmaceutical Anti-Hemmorhoidal Ointment Formula Containing Lidocaine HCL , Bismuth Subgallate and Floucinolone Acetonide with its Stability Study. تركيبة صيدلانية عراقية لمستحضر مرهم علاج البواسير يحتوي على ليدوكايين هايدروكلورايد و بزموث سابكالات مع فلوسينولون اسيتونايد مع دراسة ثباتيتها

Abstract

Work has been carried out to develop a new national drug product oleogenous ointment containing lidocaine [ ( HCl ) (2 %) ] , bismuth subgallate (5 %) and floucinolone acetonide (0.1 %) . It is used in the treatment of hemorrhoid, anal fissures and anal pruritus. Several formulations were prepared using different ointment bases, preservatives and humectant. Selection of best formula relied solely on physico-chemical testing of sample release and stability . Stability study was conducted on the product for six months at different temperatures to determine the expiration date and the best storage conditions. From the study we obtained an anti-hemorrhoidal ointment of good homogensity, softness and adhisive.The expiry date calculated to be not less than (3) years.