Iraqi Pharmaceutical Formula for Erythromycin Topical Gel (2%) w/w for the Treatment of Acne with its Stability Study. تركيبة صيدلانية عراقية لمستحضرإرثرومايسين جل موضعي 2%) w/w) لعلاج حب الشباب مع دراسة ثباتيتها.

Abstract

This work has been carried out to develop national drug product contains (2 %) erythromycin as gel, it is used for the treatment of acne . Several gel formulations were prepared using different gels bases , preservatives and humectants. Selection of best formula relied solely on physicochemical testing of sample exposed to thermal stresses. Stability study was conducted on the product for (6) months at different temperatures to determine the expiration date and the best storage conditions. We obtained an antibiotic gel used to treat acne vulgaris of good homogeneity, softness and adhesivity. The expiry date calculated to be not less than (2) years.