Iraqi Pharmaceutical Formula for Minoxidil Topical Solution 5 % w/v for the Treatment of Hair Loss in Men with its Stability Study. تركيبة صيدلانية عراقية لمستحضر محلول مينوكسيديل الموضعي 5% وزن /حجم لعلاج تساقط الشعر عند الرجال مع دراسة ثباتيتها .

Abstract

This work has been carried out to develop national drug product contains )5 %( minoxidil as a topical solution, It is used in the treatment of alopecia (hair loss) and alopecia areata minoxidil promotes hair grow by direct dilator effect on the peripheral vessels , and also promoting the epithelium of hair bursa . Several solutions formulations were prepared using different solutions bases, preservatives and humectants. Selection of best formula relied solelyon physico-chemical testing of sample exposed to thermal stresses. Stability study was conducted on the product for (6) months at different temperatures to determine the expiration date and the best storage conditions. From the study we obtained minoxidil topical solution of good clarity. The expiry date calculated to be not less than (2) years.