Iraqi Pharmaceutical Formula for Acyclovir Oral Suspension 200 mg/5ml for Treatment of Herpes Simplex Infections with it,s Stability Study -3تركيبة صيدلانية عراقية لمستحضر اسايكلوفير معلق فموي 200ملغم/ 5مل لعلاج عدوى الهربس البسيط مع دراسة ثباتيتها

Abstract

This work has been carried out to develop national drug product contains (4 % w/v) acyclovir as oral suspension , Which is indicated for the acute treatment of herpes zoster (shingles) , is indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes is indicated for the treatment of chickenpox (varicella) and other viral infections . Several formulations were prepared using different suspensions bases, preservatives and suspending agents. Selection of the best formula relied solely on physico-chemical testing . Stability study was conducted on the product for (6) months at different temperatures to determine the expiration date and the best storage conditions. From the study good homogeneity obtained of an antiviral oral suspension . The expiry date calculated to be not less than (2.5) years.