Iraqi Pharmaceutical Formula of Ketoprofen 2.5 % w/w Topical Gel for Treatment of Inflammation and Pain of Joints and Muscles with It,s Stability Study. تركيبة صيدلانية عراقية لمستحضر كيتوبروفين 2.5 % وزن / وزن جل موضعي لعلاج التهاب وآلام المفاصل والعضلات مع دراسة ثباتيتها.

Abstract

Work has been carried out to develop a new national drug product gel containing ketoprofen 2.5% . It is used for local relief of pain and inflammation associated with rheumatic and muscular disorders and soft tissue injuries such as acute strains and sprains. Several formulations were prepared using different gel bases, preservatives and humectants. Selection of best formula relied solely on physico-chemical testing of sample exposed to thermal stresses. Stability study was conducted on the product for 6 months at different temperatures to determine the expiration date and the best storage conditions. From the study we obtained an anti-inflammatory gel of good homogeneity, softness and adhesivity. The expiration date calculated to be not less than(2)years.