Iraqi Pharmaceutical Formula for Acyclovir Cream 5% w/w for Treating Cold Sores on the Face or Lips that are Caused by the Herpes Virus with its Stability Study.

Abstract

This work has been carried out to develop national drug product contains (5 %)acyclovir as cream, it is used fortreatment of cold sores or genital herpes .Several cream formulations were prepared using different creams bases, preservatives and humectants. Selection of best formula relied solely on physico-chemical testing of sample exposed to thermal stresses. Stability study was conducted on the product for (6) months at different temperatures to determine the expiration date and the best storage conditions. From the study we obtained an antiviral cream of good homogeneity, softness and adhesivity.The expiry date calculated to be not less than (2) years.