Formulation of Simethicone 40mg/ml as an Oral Dropتصييغ السميثيكون 40 ملغم /مل كقطرة فموية

Abstract

The present work has been carried out to develop pharmaceutical product contains (40mg/ml) simethicone as an oral drop. The drop it is used as an antiflatulent in infants and children.Different batches have been prepared including different oral drop bases and preservatives.Selection for better combination relied solely on physical and chemical testing of samples. Stability study was conducted on the product for(6) months at different temperatures (25,40,50,60) °C to determine the expiration date and the best storage conditions. From this study we obtained oral drops suspension as an antiflatulent, of good homogeneity. The expiry date calculated to be not less than (2) years From the date of production