Formulation of Diazepam Rectal Enema Solution 0.05 % ( w/v)تصييغ مستحضر ديازيبام محلول شرجي 0,05% (وزن / حجم)

Abstract

Several aqueous formulations were prepared using different solvents, ethanol (96%), propylene glycol, benzoic acid, sodium benzoate and purified water. The best formula was selected for physicochemical testing and further exposed to thermal stresses. This work has been carried out to formulation pharmaceutical product contains diazepam (0.05 %)( w/v) as rectal enema solution, it is used in emergency situations to control seizures, such as status epileptic and febrile convulsions in children. The stability study was conducted on the product for (6) months at different temperatures to determine the expiration date and the best storage conditions. The selected formula which contains (diazepam, ethanol (96%), propylene glycol, benzoic acid, sodium benzoate and purified Water) shows acceptable physical properties with estimated shelf life about (3) years .