Formulation and Evaluation of Progesterone Vaginal Suppositories 200mg. Used for Infertility of Women.

Abstract

This work has been carried out to develop pharmaceutical product contains containing progesterone (200 mg) as suppositories, which is used infertility treatment as a part of assist reproductive system for infertility women unable of pregnancy due to a lack of natural progesterone hormone Several formulations were prepared using different suppositories bases, preservatives and humectants. Selection of the best formula relied solely on physicochemical testing of sample exposed to thermal stresses. Stability study was conducted on the product for (6) months at different temperatures ( 2-8 ◦C,25◦C , 30 ◦C ) to determine the expiration date and the best storage conditions. The results revealed a promised suppositories of good homogeneity, smoothness and hardness . The expiry date calculated to be not less than (3) years.